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$45.71+0.94|(+2.10%)
52W H: 24052W L: 7.88Beta: 3.63

About Spruce Biosciences, Inc

Frequently Asked Questions

What is the 52-week range for SPRB?

The 52-week high is $240 and the 52-week low is $7.88.

What is the P/E ratio for SPRB?

The P/E ratio data is currently unavailable.

What is the dividend yield for SPRB?

This company does not currently pay a dividend or the data is unavailable.

What is the Return on Equity (ROE)?

The trailing twelve months (TTM) Return on Equity is -155.40%.

What is the Net Profit Margin?

The Net Profit Margin (TTM) is -1079.94%.

What is the Price to Book (P/B) Ratio?

The annual Price to Book ratio stands at 2.19.

Analyst Recommendation Trends

Wall Street analyst consensus for SPRB over the last few months:

2026-09-01
Buy: 8
S.Buy: 5
Hold: 1
Sell: 0
2026-08-01
Buy: 8
S.Buy: 5
Hold: 1
Sell: 0
2026-07-01
Buy: 7
S.Buy: 5
Hold: 1
Sell: 0
2026-06-01
Buy: 6
S.Buy: 4
Hold: 1
Sell: 0

Latest SPRB News

Citizens Reiterates Market Outperform on Spruce Biosciences, Maintains $144 Price Target

Citizens analyst Jonathan Wolleben reiterates Spruce Biosciences (NASDAQ:SPRB) with a Market Outperform and maintains $144 price target.

Benzinga9/24/2026

Lake Street Initiates Coverage On Spruce Biosciences with Buy Rating, Announces Price Target of $149

Lake Street analyst Daniel Brims initiates coverage on Spruce Biosciences (NASDAQ:SPRB) with a Buy rating and announces Price Target of $149.

Benzinga9/17/2026

Spruce Biosciences to Participate in the H.C. Wainwright 28th Annual Global Investment Conference

SOUTH SAN FRANCISCO, Calif., September 08, 2026--Spruce Biosciences, Inc. (Nasdaq: SPRB), a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need, today announced that Javier Szwarcberg, M.D., M.P.H., Chief Executive Officer, will present at the H.C. Wainwright 28th Annual Global Investment Conference on September 15, 2026, at 2:00 p.m. ET in New York.

Yahoo9/8/2026

Related Stocks (Peers)

Companies operating in similar sectors to SPRB:

HUMAOTLKKRROPMVPRNASPRBARMPCRBUCBUSTNYAVTVTHURA950160.KQ

Recent Insider Transactions

DateNameShares ChangedPriceValue
2026-07-27Quartel Adrian W+13,000--
2026-06-30Szwarcberg Javier B.+266$4.5305$1,205
2026-05-21Walbert Keli+1,700--
2026-05-21Barretto-Ko Percival+1,700--
2026-05-21SIMPSON CAMILLA V+1,700--
2026-05-21GREY MICHAEL G+1,700--
2026-05-21SPIEGELMAN DANIEL K+1,700--
2026-03-09Hooks Corwin Dale+11,000--
2025-12-31Szwarcberg Javier B.+4,690$4.5305$21,248
2025-12-15Szwarcberg Javier B.-1,196--
2025-12-15Szwarcberg Javier B.-1,480--
2025-12-15Szwarcberg Javier B.-608$80.67$49,047
2025-12-15Szwarcberg Javier B.+1,196--
2025-12-15Szwarcberg Javier B.-752$80.67$60,664
2025-12-15Szwarcberg Javier B.+1,480--
2025-12-15Gharib Samir M.-513--
2025-12-15Gharib Samir M.-496--
2025-12-15Gharib Samir M.-184$80.67$14,843
2025-12-15Gharib Samir M.+513--
2025-12-15Gharib Samir M.-178$80.67$14,359
2025-12-15Gharib Samir M.+496--
2025-12-11Ways Douglas Kirk-400--
2025-12-11Ways Douglas Kirk+400--
2025-12-11Ways Douglas Kirk-266--
2025-12-11Ways Douglas Kirk+266--
2025-12-11Ways Douglas Kirk-1,250--
2025-12-11Ways Douglas Kirk+5,000--
2025-12-11Ways Douglas Kirk+1,250--
2025-12-11Szwarcberg Javier B.-1,666--
2025-12-11Szwarcberg Javier B.+1,666--
2025-12-11Walbert Keli+3,400--
2025-12-11Barretto-Ko Percival-800--
2025-12-11Barretto-Ko Percival+800--
2025-12-11Szwarcberg Javier B.-10,000--
2025-12-11Szwarcberg Javier B.+10,000--
2025-12-11SIMPSON CAMILLA V-400--
2025-12-11SIMPSON CAMILLA V+400--
2025-12-11SIMPSON CAMILLA V-133--
2025-12-11SIMPSON CAMILLA V+133--
2025-12-11SIMPSON CAMILLA V-362--
2025-12-11SIMPSON CAMILLA V+362--
2025-12-11SIMPSON CAMILLA V-309--
2025-12-11SIMPSON CAMILLA V+309--
2025-12-11SIMPSON CAMILLA V-173--
2025-12-11SIMPSON CAMILLA V+173--
2025-12-11Gharib Samir M.-933--
2025-12-11Gharib Samir M.+933--
2025-12-11Gharib Samir M.-1,933--
2025-12-11Gharib Samir M.+1,933--
2025-12-11Gharib Samir M.-733--
2025-12-11Gharib Samir M.+733--
2025-12-11Gharib Samir M.-953--
2025-12-11Gharib Samir M.+953--
2025-12-11Gharib Samir M.-1,579--
2025-12-11Gharib Samir M.+1,579--
2025-12-11GREY MICHAEL G-400--
2025-12-11GREY MICHAEL G+400--
2025-12-11GREY MICHAEL G-666--
2025-12-11GREY MICHAEL G+666--
2025-12-11GREY MICHAEL G-133--
2025-12-11GREY MICHAEL G+133--
2025-12-11GREY MICHAEL G-1,499--
2025-12-11GREY MICHAEL G+1,499--
2025-12-11GREY MICHAEL G-1,255--
2025-12-11GREY MICHAEL G+1,255--
2025-12-11GREY MICHAEL G-387--
2025-12-11GREY MICHAEL G+387--
2025-12-11SPIEGELMAN DANIEL K-400--
2025-12-11SPIEGELMAN DANIEL K+400--
2025-12-11SPIEGELMAN DANIEL K-88--
2025-12-11SPIEGELMAN DANIEL K+88--
2025-12-11SPIEGELMAN DANIEL K-458--
2025-12-11SPIEGELMAN DANIEL K+458--
2025-12-11Szwarcberg Javier B.-4,950--
2025-12-11Szwarcberg Javier B.+19,800--
2025-12-11Szwarcberg Javier B.-2,194$88.41$193,972
2025-12-11Szwarcberg Javier B.+4,950--
2025-12-11Gharib Samir M.-1,900--
2025-12-11Gharib Samir M.+7,600--
2025-12-11Gharib Samir M.-680$88.41$60,119
2025-12-11Gharib Samir M.+1,900--
2025-12-10Szwarcberg Javier B.-1,196--
2025-12-10Szwarcberg Javier B.-428$85.67$36,667
2025-12-10Szwarcberg Javier B.+1,196--
2025-12-10Gharib Samir M.-514--
2025-12-10Gharib Samir M.-184$85.67$15,763
2025-12-10Gharib Samir M.+514--
2025-10-20Szwarcberg Javier B.-4,784--
2025-10-20Szwarcberg Javier B.+4,784--
2025-10-20Szwarcberg Javier B.-1,539$148.16$228,018
2025-10-20Szwarcberg Javier B.+4,784--
2025-10-20Gharib Samir M.-2,053--
2025-10-20Gharib Samir M.+2,053--
2025-10-20Gharib Samir M.-661$148.16$97,934
2025-10-20Gharib Samir M.+2,053--
2025-10-06Parkman Healthcare Partners LLC-25$17.4557$436
2025-10-06Parkman Healthcare Partners LLC-232$19.3264$4,484
2025-10-06Parkman Healthcare Partners LLC+256$17.9108$4,585
2025-10-06Parkman Healthcare Partners LLC-25$17.4557$436
2025-10-06Parkman Healthcare Partners LLC-232$19.3264$4,484
2025-10-06Parkman Healthcare Partners LLC+256$17.9108$4,585