$4.914.91 -0.19-0.19 |(-3.73-3.73 %)
Analyst Recommendation Trends
Wall Street analyst consensus for SION over the last few months:
2026-09-01
Buy: 4
S.Buy: 2
Hold: 11
Sell: 0
2026-08-01
Buy: 7
S.Buy: 7
Hold: 2
Sell: 1
2026-07-01
Buy: 7
S.Buy: 7
Hold: 2
Sell: 1
2026-06-01
Buy: 7
S.Buy: 7
Hold: 2
Sell: 1
Latest SION News
Sionna Therapeutics (SION) Approves 46% Job Cut. Can a New Trial Make its Cash More Productive?
Sionna Therapeutics, Inc. (NASDAQ:SION) announced on September 14 that its board approved an approximately 46% workforce reduction as it concentrates development on SION-451 plus SION-2222 for cystic fibrosis. Sionna Therapeutics, Inc. (NASDAQ:SION) ended the second quarter with approximately $268.3 million in cash, cash equivalents, and marketable securities. Management estimates that the workforce reduction, discontinued investment […]
Yahoo9/17/2026
SION to Cut Workforce by Nearly Half After CF Study Failure, Stock Down
Sionna set to reduce its workforce by 46% after SION-719 fails a key CF study, shifting focus to SION-451 + SION-2222.
Yahoo9/16/2026
FDA clears first generic radioligand drug; Sionna turns to layoffs
A Lutathera copycat has become the first “radioligand equivalent” cleared by regulators. Elsewhere, Novo dropped the “Nordisk” from its name and a novel RNAi drug showed early promise.
Yahoo9/15/2026
Sionna Therapeutics, Inc. (SION) Discusses Post-Hoc Analysis of PreciSION CF Trial and Advancement of Dual Combination Program - Slideshow
2026-09-15. The following slide deck was published by Sionna Therapeutics, Inc.
SeekingAlpha9/15/2026
Wedbush Maintains Neutral on Sionna Therapeutics, Raises Price Target to $6
Wedbush analyst Laura Chico maintains Sionna Therapeutics (NASDAQ:SION) with a Neutral and raises the price target from $5 to $6.
Benzinga9/15/2026
Sionna Therapeutics, Inc. (SION) Discusses Post-Hoc Analysis of PreciSION CF Trial and Advancement of Dual Combination Program Transcript
Sionna Therapeutics, Inc. (SION) Discusses Post-Hoc Analysis of PreciSION CF Trial and Advancement of Dual Combination Program September 14, 2026 4:30 PM...
SeekingAlpha9/15/2026
Sionna Therapeutics Announces Plans to Advance SION-451 + SION-2222 Dual Combination into Phase 2a Proof-of-Concept Trial
Post hoc analyses of SION-719 PreciSION CF subset showed a mean placebo-adjusted sweat chloride reduction of up to -8.6 mmol/L consistent with NBD1 biological activity Dual combination Phase 2a trial expected to initiate in first quarter of 2027 46% workforce reduction and other cost-saving measures prioritize advancing the dual combination program and extend cash runway into the second half of 2029 Sionna to host conference call today at 4:30 p.m. ET WALTHAM, Mass., Sept. 14, 2026 (GLOBE NEWSWI
Yahoo9/14/2026
Sionna Therapeutics To Advance SION-451/SION-2222 CF Combo Into Phase 2a; Cuts Workforce By 46% To Extend Cash Runway Into The Second Half Of 2029
Post hoc analyses of SION-719 PreciSION CF subset showed a mean placebo-adjusted sweat chloride reduction of up to -8.6 mmol/L consistent with NBD1 biological activityDual combination Phase 2a trial expected to initiate
Benzinga9/14/2026
Related Stocks (Peers)
Recent Insider Transactions
| Date | Name | Shares Changed | Price | Value |
|---|---|---|---|---|
| 2026-09-17 | Fitzpatrick Jennifer | -103,140 | - | - |
| 2026-09-17 | Fitzpatrick Jennifer | +103,140 | - | - |
| 2026-09-17 | Fitzpatrick Jennifer | +28,132 | - | - |
| 2026-09-17 | Fitzpatrick Jennifer | +28,133 | - | - |
| 2026-09-17 | McKee Charlotte | -155,700 | - | - |
| 2026-09-17 | McKee Charlotte | +155,700 | - | - |
| 2026-09-17 | McKee Charlotte | +50,000 | - | - |
| 2026-09-17 | McKee Charlotte | +50,000 | - | - |
| 2026-09-17 | Ridloff Elena | -165,440 | - | - |
| 2026-09-17 | Ridloff Elena | +165,440 | - | - |
| 2026-09-17 | Ridloff Elena | +47,268 | - | - |
| 2026-09-17 | Ridloff Elena | +47,269 | - | - |
| 2026-09-17 | Cloonan Michael | -436,100 | - | - |
| 2026-09-17 | Cloonan Michael | +436,100 | - | - |
| 2026-09-17 | Cloonan Michael | +109,025 | - | - |
| 2026-09-17 | Cloonan Michael | +109,025 | - | - |
| 2026-09-17 | RA CAPITAL MANAGEMENT, L.P. | -33,800 | $7.46 | $252,148 |
| 2026-09-17 | RA CAPITAL MANAGEMENT, L.P. | -3,415,011 | $6.32 | $21,582,870 |
| 2026-07-07 | Thompson Peter A. | -85,918 | $44.86 | $3,854,281 |
| 2026-07-07 | ORBIMED ADVISORS LLC | -85,918 | $44.86 | $3,854,281 |
| 2026-07-06 | Fitzpatrick Jennifer | -10,250 | - | - |
| 2026-07-06 | Fitzpatrick Jennifer | -10,250 | $43.5963 | $446,862 |
| 2026-07-06 | Fitzpatrick Jennifer | +10,250 | $6.11 | $62,628 |
| 2026-06-30 | Thompson Peter A. | -115,844 | $45.5 | $5,270,902 |
| 2026-06-30 | ORBIMED ADVISORS LLC | -115,844 | $45.5 | $5,270,902 |
| 2026-06-17 | Stelzer Laurie | +17,340 | - | - |
| 2026-06-17 | Booth Bruce | +17,340 | - | - |
| 2026-06-17 | Clancy Paul J | +17,340 | - | - |
| 2026-06-17 | Thompson Peter A. | +17,340 | - | - |
| 2026-06-17 | RA Capital Healthcare Fund LP | +17,340 | - | - |
| 2026-05-27 | Thompson Peter A. | -101 | $44.49 | $4,493 |
| 2026-05-27 | ORBIMED ADVISORS LLC | -101 | $44.49 | $4,493 |
| 2026-05-11 | Thompson Peter A. | -184,639 | $46.22 | $8,534,015 |
| 2026-05-11 | ORBIMED ADVISORS LLC | -184,639 | $46.22 | $8,534,015 |
| 2026-05-08 | Thompson Peter A. | -59,767 | $44.58 | $2,664,413 |
| 2026-05-08 | ORBIMED ADVISORS LLC | -59,767 | $44.58 | $2,664,413 |
| 2026-05-07 | Thompson Peter A. | -48,546 | $44.61 | $2,165,637 |
| 2026-05-07 | ORBIMED ADVISORS LLC | -48,546 | $44.61 | $2,165,637 |
| 2026-04-18 | Thompson Peter A. | -2,948 | $44.52 | $131,245 |
| 2026-04-18 | ORBIMED ADVISORS LLC | -2,948 | $44.52 | $131,245 |
| 2026-04-17 | Thompson Peter A. | -52,397 | $44.68 | $2,341,098 |
| 2026-04-17 | ORBIMED ADVISORS LLC | -52,397 | $44.68 | $2,341,098 |
| 2026-04-16 | Thompson Peter A. | -226,906 | $45.34 | $10,287,918 |
| 2026-04-16 | ORBIMED ADVISORS LLC | -226,906 | $45.34 | $10,287,918 |
| 2026-04-15 | Thompson Peter A. | -235,863 | $44.64 | $10,528,924 |
| 2026-04-15 | ORBIMED ADVISORS LLC | -235,863 | $44.64 | $10,528,924 |
| 2026-04-14 | Thompson Peter A. | -47,814 | $44.51 | $2,128,201 |
| 2026-04-14 | ORBIMED ADVISORS LLC | -47,814 | $44.51 | $2,128,201 |
| 2026-03-05 | Fitzpatrick Jennifer | -10,250 | - | - |
| 2026-03-05 | Fitzpatrick Jennifer | -10,250 | $33.8555 | $347,019 |
| 2026-03-05 | Fitzpatrick Jennifer | +10,250 | $6.11 | $62,628 |
| 2026-02-03 | Thompson Peter A. | -29,063 | $44.58 | $1,295,629 |
| 2026-02-03 | ORBIMED ADVISORS LLC | -29,063 | $44.58 | $1,295,629 |
| 2026-02-02 | Thompson Peter A. | -1,890 | $44.57 | $84,237 |
| 2026-02-02 | ORBIMED ADVISORS LLC | -1,890 | $44.57 | $84,237 |
| 2026-01-22 | COULTER JAMES G | -250,000 | $40 | $10,000,000 |
| 2026-01-02 | Beer Caroline Stark | +139,340 | - | - |
| 2026-01-02 | Fitzpatrick Jennifer | +103,140 | - | - |
| 2026-01-02 | McKee Charlotte | +155,700 | - | - |
| 2026-01-02 | Ridloff Elena | +165,440 | - | - |
| 2026-01-02 | Cloonan Michael | +436,100 | - | - |
| 2025-12-24 | Thompson Peter A. | -33,356 | $44.55 | $1,486,010 |
| 2025-12-24 | ORBIMED ADVISORS LLC | -33,356 | $44.55 | $1,486,010 |
| 2025-12-19 | Thompson Peter A. | -875 | $44.49 | $38,929 |
| 2025-12-19 | ORBIMED ADVISORS LLC | -875 | $44.49 | $38,929 |
| 2025-12-18 | Thompson Peter A. | -100 | $44.49 | $4,449 |
| 2025-12-18 | ORBIMED ADVISORS LLC | -100 | $44.49 | $4,449 |
| 2025-12-17 | Thompson Peter A. | -900 | $44.5 | $40,050 |
| 2025-12-17 | ORBIMED ADVISORS LLC | -900 | $44.5 | $40,050 |
| 2025-12-05 | Fitzpatrick Jennifer | -10,250 | - | - |
| 2025-12-05 | Fitzpatrick Jennifer | -10,250 | $40.52 | $415,330 |
| 2025-12-05 | Fitzpatrick Jennifer | +10,250 | $6.11 | $62,628 |
| 2025-11-26 | Thompson Peter A. | -1,600 | $44.49 | $71,184 |
| 2025-11-26 | ORBIMED ADVISORS LLC | -1,600 | $44.49 | $71,184 |
| 2025-11-25 | Thompson Peter A. | -11,890 | $44.6 | $530,294 |
| 2025-11-25 | ORBIMED ADVISORS LLC | -11,890 | $44.6 | $530,294 |
| 2025-11-24 | Thompson Peter A. | -94,583 | $44.54 | $4,212,727 |
| 2025-11-24 | ORBIMED ADVISORS LLC | -94,583 | $44.54 | $4,212,727 |
| 2025-11-21 | RA Capital Healthcare Fund LP | -7,609 | $39.5 | $300,556 |
| 2025-11-21 | RA Capital Healthcare Fund LP | -6,440 | $39.5 | $254,380 |
| 2025-11-21 | RA Capital Healthcare Fund LP | -9,924 | $39.5 | $391,998 |
| 2025-11-21 | RA Capital Healthcare Fund LP | -1,210 | $39.5 | $47,795 |
| 2025-11-20 | RA Capital Healthcare Fund LP | -604 | $40.5 | $24,462 |
| 2025-11-20 | RA Capital Healthcare Fund LP | -512 | $40.5 | $20,736 |
| 2025-11-20 | RA Capital Healthcare Fund LP | -788 | $40.5 | $31,914 |
| 2025-11-20 | RA Capital Healthcare Fund LP | -96 | $40.5 | $3,888 |
| 2025-11-20 | RA Capital Healthcare Fund LP | -947 | $39.89 | $37,776 |
| 2025-11-20 | RA Capital Healthcare Fund LP | -801 | $39.89 | $31,952 |
| 2025-11-20 | RA Capital Healthcare Fund LP | -1,235 | $39.89 | $49,264 |
| 2025-11-20 | RA Capital Healthcare Fund LP | -150 | $39.89 | $5,984 |
| 2025-11-19 | RA Capital Healthcare Fund LP | -9 | $40.61 | $365 |
| 2025-11-19 | RA Capital Healthcare Fund LP | -8 | $40.61 | $325 |
| 2025-11-19 | RA Capital Healthcare Fund LP | -12 | $40.61 | $487 |
| 2025-11-19 | RA Capital Healthcare Fund LP | -2 | $40.61 | $81 |
| 2025-11-19 | RA Capital Healthcare Fund LP | -14,325 | $40.01 | $573,143 |
| 2025-11-19 | RA Capital Healthcare Fund LP | -12,126 | $40.01 | $485,161 |
| 2025-11-19 | RA Capital Healthcare Fund LP | -18,684 | $40.01 | $747,547 |
| 2025-11-19 | RA Capital Healthcare Fund LP | -2,276 | $40.01 | $91,063 |
| 2025-11-18 | RA Capital Healthcare Fund LP | -2,092 | $39.57 | $82,780 |
| 2025-11-18 | RA Capital Healthcare Fund LP | -1,770 | $39.57 | $70,039 |
| 2025-11-18 | RA Capital Healthcare Fund LP | -2,728 | $39.57 | $107,947 |
| 2025-11-18 | RA Capital Healthcare Fund LP | -332 | $39.57 | $13,137 |
| 2025-11-17 | RA Capital Healthcare Fund LP | -331 | $42.1 | $13,935 |
| 2025-11-17 | RA Capital Healthcare Fund LP | -280 | $42.1 | $11,788 |
| 2025-11-17 | RA Capital Healthcare Fund LP | -433 | $42.1 | $18,229 |
| 2025-11-17 | RA Capital Healthcare Fund LP | -53 | $42.1 | $2,231 |
| 2025-11-17 | RA Capital Healthcare Fund LP | -10,707 | $41.05 | $439,522 |
| 2025-11-17 | RA Capital Healthcare Fund LP | -9,063 | $41.05 | $372,036 |
| 2025-11-17 | RA Capital Healthcare Fund LP | -13,964 | $41.05 | $573,222 |
| 2025-11-17 | RA Capital Healthcare Fund LP | -1,701 | $41.05 | $69,826 |
| 2025-11-17 | RA Capital Healthcare Fund LP | -13,734 | $40.2 | $552,107 |
| 2025-11-17 | RA Capital Healthcare Fund LP | -11,626 | $40.2 | $467,365 |
| 2025-11-17 | RA Capital Healthcare Fund LP | -17,913 | $40.2 | $720,103 |
| 2025-11-17 | RA Capital Healthcare Fund LP | -2,182 | $40.2 | $87,716 |
| 2025-10-28 | RA Capital Healthcare Fund LP | -10,476 | $39.58 | $414,640 |
| 2025-10-28 | RA Capital Healthcare Fund LP | -17,118 | $39.58 | $677,530 |
| 2025-10-28 | RA Capital Healthcare Fund LP | -31,392 | $39.58 | $1,242,495 |
| 2025-10-28 | RA Capital Healthcare Fund LP | -3,624 | $39.58 | $143,438 |
| 2025-10-24 | RA Capital Healthcare Fund LP | -107,941 | $39.5 | $4,263,670 |
| 2025-10-24 | RA Capital Healthcare Fund LP | -66,672 | $39.5 | $2,633,544 |
| 2025-10-24 | RA Capital Healthcare Fund LP | -122,271 | $39.5 | $4,829,705 |
| 2025-10-24 | RA Capital Healthcare Fund LP | -14,116 | $39.5 | $557,582 |
| 2025-10-21 | Booth Bruce | -17 | $36.42 | $619 |
| 2025-10-21 | Booth Bruce | -83 | $36.42 | $3,023 |
| 2025-10-21 | Booth Bruce | -5,316 | $35.69 | $189,728 |
| 2025-10-21 | Booth Bruce | -25,327 | $35.69 | $903,921 |
| 2025-10-21 | Booth Bruce | -1,210 | $34.91 | $42,241 |
| 2025-10-21 | Booth Bruce | -5,763 | $34.91 | $201,186 |
| 2025-10-21 | Booth Bruce | -4,187 | $33.87 | $141,814 |
| 2025-10-21 | Booth Bruce | -19,948 | $33.87 | $675,639 |
| 2025-10-21 | Booth Bruce | -4,688 | $32.69 | $153,251 |
| 2025-10-21 | Booth Bruce | -22,339 | $32.69 | $730,262 |
| 2025-10-21 | Cloonan Michael | -33,532 | - | - |
| 2025-10-21 | Cloonan Michael | -22,895 | - | - |
| 2025-10-21 | Cloonan Michael | -30,049 | - | - |
| 2025-10-21 | Cloonan Michael | -13,324 | - | - |
| 2025-10-21 | Cloonan Michael | -33,532 | $37.31 | $1,251,079 |
| 2025-10-21 | Cloonan Michael | +33,532 | $6.11 | $204,881 |
| 2025-10-21 | Cloonan Michael | -22,895 | $36.6 | $837,957 |
| 2025-10-21 | Cloonan Michael | +22,895 | $6.11 | $139,888 |
| 2025-10-21 | Cloonan Michael | -30,049 | $35.63 | $1,070,646 |
| 2025-10-21 | Cloonan Michael | +30,049 | $6.11 | $183,599 |
| 2025-10-21 | Cloonan Michael | -13,324 | $34.44 | $458,879 |
| 2025-10-21 | Cloonan Michael | +13,324 | $6.11 | $81,410 |
| 2025-10-20 | Booth Bruce | -5,412 | $32.33 | $174,970 |
| 2025-10-20 | Booth Bruce | -25,788 | $32.33 | $833,726 |
| 2025-10-20 | Booth Bruce | -4,300 | $31.79 | $136,697 |
| 2025-10-20 | Booth Bruce | -20,485 | $31.79 | $651,218 |
| 2025-10-17 | Booth Bruce | -52 | $33.47 | $1,740 |
| 2025-10-17 | Booth Bruce | -248 | $33.47 | $8,301 |
| 2025-10-17 | Booth Bruce | -4,503 | $32.71 | $147,293 |
| 2025-10-17 | Booth Bruce | -21,451 | $32.71 | $701,662 |
| 2025-10-17 | Booth Bruce | -6,049 | $32.1 | $194,173 |
| 2025-10-17 | Booth Bruce | -28,821 | $32.1 | $925,154 |
| 2025-10-16 | Booth Bruce | -2,705 | $33.38 | $90,293 |
| 2025-10-16 | Booth Bruce | -12,888 | $33.38 | $430,201 |
| 2025-10-16 | Booth Bruce | -15,384 | $32.84 | $505,211 |
| 2025-10-16 | Booth Bruce | -73,296 | $32.84 | $2,407,041 |
| 2025-10-16 | Booth Bruce | -9,470 | $31.69 | $300,104 |
| 2025-10-16 | Booth Bruce | -45,117 | $31.69 | $1,429,758 |
| 2025-10-16 | Booth Bruce | -1,804 | $30.15 | $54,391 |
| 2025-10-16 | Booth Bruce | -8,596 | $30.15 | $259,169 |
| 2025-10-16 | Cloonan Michael | -200 | - | - |
| 2025-10-16 | Cloonan Michael | -10,225 | - | - |
| 2025-10-16 | Cloonan Michael | -200 | $34 | $6,800 |
| 2025-10-16 | Cloonan Michael | +200 | $6.11 | $1,222 |
| 2025-10-16 | Cloonan Michael | -10,225 | $31.4612 | $321,691 |
| 2025-10-16 | Cloonan Michael | +10,225 | $6.11 | $62,475 |
| 2025-10-15 | Cloonan Michael | -14,775 | - | - |
| 2025-10-15 | Cloonan Michael | -14,775 | $31.1108 | $459,662 |
| 2025-10-15 | Cloonan Michael | +14,775 | $6.11 | $90,275 |
| 2025-10-15 | Booth Bruce | -6,303 | $31.12 | $196,149 |
| 2025-10-15 | Booth Bruce | -30,032 | $31.12 | $934,596 |
| 2025-10-15 | Booth Bruce | -13,795 | $30.37 | $418,954 |
| 2025-10-15 | Booth Bruce | -65,726 | $30.37 | $1,996,099 |
| 2025-10-14 | Booth Bruce | -105 | $29.95 | $3,145 |
| 2025-10-14 | Booth Bruce | -501 | $29.95 | $15,005 |
| 2025-10-13 | Booth Bruce | -857 | $31.03 | $26,593 |
| 2025-10-13 | Booth Bruce | -4,082 | $31.03 | $126,664 |
| 2025-10-13 | Booth Bruce | -9,245 | $30.32 | $280,308 |
| 2025-10-13 | Booth Bruce | -44,048 | $30.32 | $1,335,535 |
| 2025-10-10 | Booth Bruce | -3,511 | $29.98 | $105,260 |
| 2025-10-10 | Booth Bruce | -16,727 | $29.98 | $501,475 |
| 2025-10-06 | Booth Bruce | -2,047 | $29.95 | $61,308 |
| 2025-10-06 | Booth Bruce | -9,753 | $29.95 | $292,102 |
| 2025-10-03 | Booth Bruce | -6,548 | $30 | $196,440 |
| 2025-10-03 | Booth Bruce | -31,198 | $30 | $935,940 |